Endocrine Abstracts

Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions. However, the potential involvement of PP2A in insulin’s metabolic signaling pathway is presently unknown. Brain insulin resistant state is characterized by disturbances in transducing the signal from IR/IRS/AKT, changing feeding behaviour and body weight. We showed that diet induced obese rats (DIO) have a marked increase in PP2A protein expression in the hypothalamus....

Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a side effect frequently reported in patients and animal models treated with TPM. Some studies showed that TPM may decrease energy storage, and thus increase energy expenditure and thermogenesis. However, the mechanisms by which TPM reduces body weight are not completely understood. Anorexigenic hormones such as insulin and leptin regulate the activity of d...